Tissue Engineering (bone) Lab Report Example | Topics and Well Written Essays - 750 words

Tissue Engineering (bone) - Lab Report Example The principle behind tissue engineering is to replace, regenerate, or repair damaged tissue. The common approach falls under the heading â€Å"Tissue Engineering Triad†: insertion of specific cells, the provision of signals that induce the growth of tissue, and the placement of specific cells on or inside certain scaffolds [1]. The regeneration of tissue requires the use of specific cell types for a specific tissue engineering approach. Local environmental factors also have an effect on the success of any tissue engineering approach [2]. Research states that body cells combined with scaffold biomaterials function as templates for regeneration of tissues to direct new tissue growth [3]. Hence, there is the need to understand how they interact at the cellular level. The biomaterials used may be natural or artificial. With the use of artificial materials, it is noted that their engineering is a challenge because materials that totally match the biological and mechanical bone matrix setting are yet to be produced [4]. Thus, natural materials that are intrinsic to the bone have been produced through the use of hydroxyapatite [5]. Their use has been facilitated by nanotechnology. It has been found that nano-hydroxyapatite develop a greater amount of cells, which is important for cell regeneration [6]. There are disparities when it comes to selecting the material that will imitate natural ones in the use of biomaterials [7]. Collagen is one of the main structural proteins found in the extracellular matrix. On the other hand, gelatine is a product of denaturation of collagen through the application of heat and has been widely used as a scaffold material [8]. Research studies indicate that collagen exists in many forms, but gelatine can be produced specifically through the type of collagen used to produce it [9]. On the other hand, collagen has been found to resist various proteases [10]. Thus, particular enzymes for its hydrolysis are needed [11]. Gelatine